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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T41103 | Compound 48/80 | Poly-p-methoxyphenethylmethylamine | |
Compound 48/80, also known as Poly-p-methoxyphenethylmethylamine, is a commonly utilized mast cell activator in animal and tissue models. This compound exerts its effect by stimulating trimeric G-proteins at the mast cel... | |||
T13623 | Compound 48/80 trihydrochloride | C48/80 trihydrochloride | Phospholipase |
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and hista... | |||
TN5647 | Confluentin | ||
Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxici... | |||
TN1623 | Escin IIB | Others , NOS | |
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice. | |||
TP1946 | QWF | ||
Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced... | |||
T62132 | S-777469 | ||
S-777469 is a selective, orally active agonist of the cannabinoid type 2 receptor (CB2) (Ki: 36 nM). s-777469 significantly inhibited compound 48/80-induced scratching behaviour in mice in a dose-dependent manner. s-7774... |